Table 3.
ORs (95% CI) from conditional logistic regression models for ASD per IQRe increase in air-pollutant levels in infancy (9 months after birth) mutually adjusted for pre-pregnancy and pregnancy exposures; stratified models
ORa (95% CI) | ||||
---|---|---|---|---|
NO2e | SO2e | PM10e | PM2.5e | |
All (N=83,526) | 1.08 (1.01, 1.15) | 1.21 (1.13, 1.29) | 1.04 (1.00, 1.09) | 1.06 (1.01, 1.11) |
Non-movers (N=74,834) |
1.07 (1.00, 1.15) | 1.21 (1.13, 1.29) | 1.03 (0.98, 1.08) | 1.04 (1.00, 1.10) |
Males (N=64,414) |
1.06 (0.99, 1.14) | 1.25 (1.16, 1.35) | 1.05 (1.00, 1.10) | 1.07 (1.01, 1.13) |
Females (N=19,112) |
1.12 (0.99, 1.26) | 1.11 (0.97, 1.27) | 1.01 (0.93, 1.11) | 1.02 (0.92, 1.12) |
Born 1989–1999 (N=36,190) |
1.05 (0.96, 1.14) | 1.18 (1.10, 1.27) | 1.02 (0.96, 1.08) | 1.04 (0.97, 1.11) |
Born 2000–2013 (N=47,336) |
1.10 (1.01, 1.20) | 1.34 (1.15, 1.56) | 1.06 (1.00, 1.13) | 1.09 (1.02, 1.16) |
Copenhagen/large citiesb (N=25,908) |
1.12 (1.04, 1.22) | 1.36 (1.22, 1.50) | 1.06 (1.00, 1.13) | 1.09 (1.02, 1.17) |
Provincial/ruralc (N=22,772) |
1.02 (0.89, 1.15) | 1.11 (1.00, 1.23) | 1.00 (0.92, 1.08) | 1.02 (0.94, 1.11) |
Cases from psychiatric hospitals only (N=73,174) |
1.09 (1.02, 1.16) | 1.23 (1.15, 1.32) | 1.06 (1.01, 1.11) | 1.08 (1.03, 1.14) |
Younger cases only d (N=36,472) |
1.13 (1.02, 1.24) | 1.44 (1.27, 1.62) | 1.08 (1.01, 1.16) | 1.14 (1.06, 1.23) |
adjusted for air pollution levels during pre-pregnancy, pregnancy, and post-pregnancy, as well as all other covariates (maternal age, paternal age, location of birth, neighborhood SES-employment, neighborhood SES-housing, and maternal smoking during pregnancy)
Includes Copenhagen and its suburbs, and large cities i.e. Aarhus, Odense and Aalborg
Includes larger provincial cities/towns and rural areas and small towns (< 10000 inhabitants)
Excludes AD cases with diagnosis age >= 5, Asperger/PDD-NOS cases with diagnosis age >= 10
IQRs in controls: NO2: 11.41 ug/m3; SO2: 2.80 ug/m3; PM10: 3.80 ug/m3; PM2.5: 3.61 ug/m3