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. Author manuscript; available in PMC: 2018 Dec 11.
Published in final edited form as: Curr Opin Virol. 2018 Aug 23;33:106–112. doi: 10.1016/j.coviro.2018.08.001

Figure 2. The proposed model of genome assortment and packaging in rotaviruses.

Figure 2.

(1) Within viroplasms, rotaviruses +RNAs bind viral RdRP (VP1, shown in red), and RNA capping enzyme (VP3, in blue), forming +RNA/VP1/VP3 complexes. (2) Binding of the octameric RNA-binding NSP2 (teal), causes structural remodeling of the viral +RNAs, exposing otherwise sequestered complementary sequences (sequences shown in red, blue and green). The complementary sequences promote base pairing between the different types of rotavirus +RNAs, a process representing RNA assortment. (3) The assorted RNA complex containing NSP2, VP1 and VP3, is predicted to nucleate VP2 core assembly (4). In this model, core assembly results in the displacement of +RNA-bound NSP2. RdRPs within new formed cores direct dsRNA synthesis, using +RNAs as templates (not shown). Adapted from [49].