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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Mol Psychiatry. 2018 Oct 3;24(3):431–446. doi: 10.1038/s41380-018-0255-6

Figure 2. Gene Set Enrichment analysis on the DEGs of Tyrobp−/−, APP/PSEN1;Tyrobp−/− and APP/PSEN1 mice at 8-months-old using Ingenuity Pathway Analysis (IPA).

Figure 2.

The absence of TYROBP in APP/PSEN1 mice alleviated the induction of the immune/pro-inflammatory response observed in the APP/PSEN1 mouse brain. (a) Heatmap of selected dysregulated canonical pathways in APP/PSEN1, APP/PSEN1;Tyrobp−/− and Tyrobp−/− mice and in the different comparisons. Data presented as −log(FDR). Pathways were selected for known or suspected relevance to AD pathophysiology. Full results of canonical pathway analyses are presented in Suppl. table 2 (b) Heatmap of significantly affected genes in selected affected canonical pathways. Data presented as −log2(Fold Change). Full results are presented in Suppl. table 2 (c) Heatmap of predicted activated or inhibited canonical pathways in APP/PSEN1, APP/PSEN1;Tyrobp−/− and Tyrobp−/− mice and in the different comparisons. Data presented as z-score.