Bacterial antigens |
|
|
|
|
Enterotoxigenic E. coli Heat-labile toxin B subunit (LTB) |
Carrots |
0.3% TSP |
Immunogenic and protective against CT challenge |
[15] |
|
Soybean |
2.4% TSP |
Immunogenic and partial protection against LT challenge in mice |
[4] |
Cholera toxin B subunit (CTB) |
Tomato |
0.081% TSP |
Immunogenic by oral delivery to mice |
[79] |
|
Rice |
2.1% TSP |
Immunogenic and protective against CT challenge to mice following oral administration |
[16] |
Viral antigens |
|
|
|
|
Hepatistis B virus surface antigen |
Potato |
8.5 μg g−1 FW |
Immunogenic response in humans following oral administration |
[19] |
Hepatitis B virus surface antigen fused with preS1 epitop |
Rice |
31.5 ng g−1 DW |
Immunogenic by intraperitoneal delivery to mice |
[80] |
Human group A rotavirus (VP6) protein |
Alflfa |
0.06-0.28% TSP |
Immunogenic in mice and offspring developed less severe diarrhea after challenge with simian rotavirus SA-11, indicating that antibodies generated in the dams provided passive heterotypic protection to the pups |
[81] |
Rotavirus (VP7) |
Potato tubers |
0.3-0.4% TSP |
Immunogenic in mice following oral delivery. Neutralization activity against rotavirus |
[82] |
Norwalk virus capsid protein |
Tomato Fruit and Potato |
8 and 0.4% TSP |
Elicit systemic and mucosal antibody responses in mice following oral administration |
[21] |
SARS-CoV S protein (S1) |
Tomato and tobacco leaf |
0.1% TSP |
Immunogenic to mice following oral administration |
[83] |
Smallpox recombinant vaccine virus B5 antigenic domain (pB5) |
Tobacco and Collard leaf |
Not Reported |
Antibody response in mice immunized parenterally and protects against lethal dose of vaccinia virus |
[84] |
Japanese encephalitis virus (JEV) envelope protein (E) |
Rice |
1.1-1.9 μg mg−1 TSP |
JEV specific neutralizing antibody detected in mice following intraperitoneal or oral administration |
[85] |
Protozoan antigens |
|
|
|
|
Plasmodium yoelii merozoite surface protein (PyMSP4/5) |
Tobacco |
0.02-0.04% TSP |
Induces antigen-specific antibodies in mice following parenteral delivery |
[86] |
Human vaccines (Viral/Transient expression) |
|
|
|
Bacterial antigens |
|
|
|
|
Yersinia pestis F1 and LcrV antigens |
Tobacco leaf tissue |
380 and 120 μg g−1 FW |
Immunogenic and protective in monkeys against Y. pestis following subcutaneous injection |
[57] |
Yersinia pestis F1-V antigens |
Tobacco leaf |
1 and 2 mg g−1
|
Immunogenic and protection in vaccinated guinea pigs against Y. pestis aerosol challenge |
[26] |
Viral antigens |
|
|
|
|
Smallpox recombinant vaccine virus B5 antigenic domain (pB5) |
Tobacco leaf |
Not Reported |
Antibody response in mice immunized perenterally and protective against lethal dose of vaccinia virus |
[84] |
Encoding domain III of the dengue 2 envelope protein (D2EIII) |
Tobacco |
0.28% TSP |
Retains antigenicity and immunogenicity as well as inducing neutralizing antibodies in vaccinated animals. |
[87] |
HIV entry inhibitors red algal protein griffithsin (GRFT) |
Tobacco (TMV) |
1 g kg−1 FW |
Active against HIV at picomolar concentrations, directly virucidal via binding to HIV envelope glycoproteins and capable of blocking cell-to-cell HIV transmission |
[75] |
Pathogenic avian influenza virus (H5N1 subtype) |
Tobacco |
60 mg kg−1
|
Immunogenic in mice and ferret and also protects ferrets against challenge infection with virus |
[28] |