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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Neuropsychopharmacology. 2018 Nov 16;44(3):620–628. doi: 10.1038/s41386-018-0273-8

Figure 4. Lithium shortens circadian period preferentially in cells from Li-R donors.

Figure 4.

A) In Li-R subjects the period shortening effect of lithium inversely correlates with baseline period length. Li-R subjects with long (>25.8 hr.) periods show the greatest shortening effect of lithium. B) In Li-NR subjects the relationship between baseline period length and the effect of lithium on period is attenuated and no longer significant. C) Li-R cells with long period (N=18) show significant period shortening after lithium compared to Li-R cells with short period (N=25). Lithium had no effect on period length in Li-NR with long (N=11) or short (N=4) period. * indicates p<0.05. D) Representative rhythm traces of a Li-R cell with long period after treatment with vehicle or lithium 1mM.