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. Author manuscript; available in PMC: 2019 Jul 28.
Published in final edited form as: Leukemia. 2019 Jan 28;33(7):1635–1649. doi: 10.1038/s41375-018-0368-6

Figure 5. Mice with Dnmt3aR878H/+ Npm1cA/+ AML show expansion of granulocyte-macrophage progenitor cells.

Figure 5.

(A) Representative flow cytometric gating for hematopoietic stem and progenitor cells in recipient mice transplanted with Dnmt3a+/+ Npm1+/+ or Dnmt3aR878H/+ Npm1cA/+ with MDS/MPD, MPD or AML phenotypes. (B) Frequency of LTHSC, STHSC, MPP2 and MPP3 and (C) GMP, CMP and MEP in donor-derived CD45.2+ BM cells (control, n = 2; R878H/+ cA/+ MDS/MPD, n = 2; R878H/+ cA/+ MPD, n = 3; R878H/+ cA/+ AML, n = 4). Results are from 2 independent experiments.