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ARID1A loss leads to increased H3K27ac marks.
Metagene plot and heatmap of H3K27ac sites in human pancreatic epithelial cells that are wild-type (WT) or null (KO) for ARID1A for the given gene sets. TSS = transcription start site.
(A) All genes.
(B) “Hallmark MYC Targets V2” signature from Gene Set Enrichment Analysis (GSEA).
(C) “Reactome Peptide Chain Elongation” signature from GSEA.
