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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Gut. 2018 Oct 12;68(7):1259–1270. doi: 10.1136/gutjnl-2017-315490

Figure 8.

Figure 8

EZH2 inhibition does not block IPMN growth in KrasG12D; Ptf1a-Cre; Arid1af/f (KCA) mice.

(A) Immunohistochemistry showing KCA murine cysts expressed high levels of H3K27me3.

(B) Western blot showing that Capan-1 cells treated with EPZ011989 had decreased levels of H3K27me3.

(C) Treatment plan, n = 10 for each arm (vehicle and EPZ011989). Day 1 was defined by when the first dose was given. (D) Mice treated with EPZ011989 had a lower rate of weight gain than mice treated with vehicle.

(E) Pancreata from the treatment group had decreased H3K27me3 levels on Western blot.

(F) Representative coronal section of MRI from vehicle and EPZ011989 treated KCA mice before and after treatment (arrowheads pointing to cysts, which were fluid filled, thus showing up as white signal on T2 weighted MRI). There was no difference in the change in volume after EPZ011989 treatment. AU, arbitrary unit.