Table 2.

Prenatal exposure to acid suppressant medications and risk of recurrent wheeze by age 3 years

	Exposed (n=144, cases=56)	Unexposed (n=756, cases=233)
Cox-proportional hazards*
Unadjusted	1.38 (1.03–1.85)†	1.00 (reference)
Adjusted Model A	1.40 (1.03–1.89)†	1.00 (reference)
Adjusted Model B	1.40 (1.02–1.91)†	1.00 (reference)

^*All models were stratified by age at enrollment.

Model A: Adjusted for sex, insurance, race/ethnicity and median household income.

Model B: Adjusted for sex, insurance, race/ethnicity, median household income, maternal history of atopic disease (asthma, allergic rhinitis, food allergy and eczema), maternal smoking during pregnancy, gestational age at birth, multiple gestation (e.g. twin), mode of delivery and maternal use of antibiotics during pregnancy prior to labor.

^†Statistically significant with P <0.05.