Table 1.

Anti-bacterial Activity of amSPC compounds

		MIC (μg ml−1)
Pathogen		1950	1951	2241	2324	SPTa
B. mallei	MIC Rangeb	3.13-50	3.13-50	3.13-50	1.56-50	8-16
	MIC50	6.3	6.3	6.3	6.3	8
	MIC90	12.5	12.5	12.5	12.5	16
Brucella spp.c	MIC Rangeb	0.4-12.5	0.4-12.5	0.4-12.5	≤0.2-6.3	1-32
	MIC50	1.56	3.13	1.56	1.56	4
	MIC90	3.13	6.25	3.13	6.25	8
F. tularensis	MIC Rangeb	1.56-200	3.13-200	3.13-200	1.56-200	1- >64
	MIC50	12.5	6.25	12.5	6.25	64
	MIC90	100	50	50	50	>64
B. anthracis	MIC Rangeb	12.5-100	6.25-50	3.13-25	12.5-50	16- >64
	MIC50	25	25	12.5	25	64
	MIC90	50	50	12.5	25	64
Y. pestis CO92	MIC	50	50	25	50	32
B. pseudomalleid	MIC	>200	>200	>200	>200	>64

^aSPT: Spectinomycin

^bThe range of MIC values for 29 strains of B. mallei, 29 strains of Brucella spp., 26 strains of F. tularensis, and 30 strains of B. anthracis

^cBrucella species tested: B. abortus, B. suis, B. melitensis

^dMIC was the same for all 10 B. pseudomallei strains tested