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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Cancer Immunol Immunother. 2019 Apr 27;68(6):999–1009. doi: 10.1007/s00262-019-02342-8

Figure 3: Intratumoral expression of PD-L1 and its impact on outcomes.

Figure 3:

(a) Representative IHC staining of PD-L1 in FFPE tumor sections of grade I, II, and III meningiomas. (b) Quantification of intratumoral PD-L1 by grade. Grade III tumors (50%) had greater PD-L1 positivity compared to grade I (35%) and II (38%) tumors. (c) Representative immunofluorescent staining of PD-L1 and CD68 in FFPE tumor sections. (d) Quantification of macrophage infiltration by tumor grade. Compared to grade I meningiomas, grade III tumors had significantly decreased CD68+ cell infiltration (* p < 0.05). (e) Intratumoral PD-L1 was not correlated with PFS.