Table 1.
Characteristics of patients according to tertiles of Urine Klotho/Cr
| Tertile 1 | Tertile 2 | Tertile 3 | ||
|---|---|---|---|---|
| Range, fmol/mg | ≤11.4 | 11.7 to 21.2 | 22.3 to 92.8 | P-value |
| Number of patients | 33 | 33 | 33 | |
| Demographics | ||||
| Age, years ± SD | 56.9 ± 17.3 | 61.0 ± 14.6 | 53.5 ± 15.3 | 0.16 |
| Women, n (%) | 16 (48.5) | 11 (33.3) | 15 (45.5) | 0.44 |
| White race, n (%) | 23 (69.7) | 22 (66.7) | 24 (72.7) | 0.77 |
| BMI, kg/m2, years ± SD | 30.4 ± 9.8 | 27.5 ± 6.8 | 27.3 ± 7.5 | 0.23 |
| Baseline kidney function | ||||
| eGFR, ml/min/1.73m2, (median IQR) | 90.2 [70.1, 100.2] | 91.9 [78.9, 100.2] | 96.6 [83.7, 103.0] | 0.49 |
| SCr, mg/dl, (median IQR) | 0.9 [0.7, 1.0] | 0.9 [0.6, 1.0] | 0.9 [0.7, 1.0] | 0.82 |
| Dipstick proteinuria >30 mg/dl, n (%) | 24 (72.7) | 11 (33.3) | 7 (21.2) | <0.0001 |
| Comorbidity | ||||
| Diabetes, n (%) | 13 (39.4) | 6 (18.2) | 6 (18.2) | 0.09 |
| Hypertension, n (%) | 20 (60.6) | 16 (48.5) | 19 (57.6) | 0.67 |
| Congestive heart failure, n (%) | 11 (33.3) | 10 (30.3) | 9 (27.3) | 0.96 |
| COPD, n (%) | 6 (18.2) | 3 (9.1) | 6 (18.2) | 0.54 |
| Liver disease, n (%) | 11 (33.3) | 6 (18.2) | 4 (12.1) | 0.14 |
| Anemia, n (%) | 29 (87.9) | 18 (54.6) | 23 (69.7) | 0.01 |
| Cancer, n (%) | 15 (45.5) | 16 (50.0) | 14 (42.4) | 0.85 |
| Charlson Index, (median IQR) | 5 [2, 8] | 3 [2, 5] | 2 [2, 4] | 0.008 |
| Critical illness parameters | ||||
| CFB 72 hours, liters, (median IQR) | 5.0 [2.1, 8.0] | 1.7 [−0.1, 4.3] | 1.0 [−0.3, 2.9] | 0.004 |
| CFB ICU stay, liters, (median IQR) | 8.5 [0.9, 14] | 1.7 [−0.1, 4.6] | 1.0 [−2, 3.5] | 0.003 |
| Pressor or inotrope, n (%) | 21 (63.6) | 14 (42.4) | 11 (33.3) | 0.04 |
| Mechanical ventilation, n (%) | 22 (66.7) | 15 (45.5) | 11 (33.3) | 0.03 |
| PRBC transfusion, n (%) | 21 (63.6) | 13 (39.4) | 9 (27.3) | 0.01 |
| Non-renal APACHE II score, (median IQR) | 18 [15, 22] | 18 [12, 20] | 11 [7, 17] | 0.004 |
| Non-renal SOFA score, (median IQR) | 8 [4, 11] | 6 [1, 8] | 2 [1, 6] | 0.0008 |
APACHE II = Acute Physiology and Chronic Health Evaluation II (the points related to SCr were subtracted from the total score); BMI = body mass index; CFB = cumulative fluid balance; COPD = chronic obstructive pulmonary disease; eGFR = estimated glomerular filtration rate (CKD-EPI equation); PRBC = packed red blood cell; SCr = serum creatinine; SOFA = Sequential Organ Failure Assessment (the points related to SCr were subtracted from the total score)