Table 2.

Association of biomarkers with MAKE-90 outcome (death, RRT-dependency, 50% decrease in eGFR)

			Tertile 1		Tertile 2		Tertile 3	Per 1-fold higher
			OR (95% CI)		OR (95% CI)		OR (95% CI)	OR (95% CI)
Urine Klotho		Range, pM		≤6.0		6.8 to 21.1	22.0 to 67.4
		No. of patients		36		30	33
		No. of MAKE-90		22		9	7
		Model 1		1.00 (Ref)		0.20 (0.06, 0.66)	0.21 (0.07, 0.67)	0.52 (0.32, 0.87)
		Model 2		1.00 (Ref)		0.23 (0.07, 0.82)	0.21 (0.06, 0.71)	0.50 (0.30, 0.86)
Urine Klotho/Cr		Range, fmol/mg		≤11.4		11.7 to 21.2	22.3 to 92.8
		No. of patients		33		33	33
		No. of MAKE-90		25		10	3
		Model 1		1.00 (Ref)		0.18 (0.05, 0.56)	0.04 (0.01, 0.19)	0.17 (0.07, 0.39)
		Model 2		1.00 (Ref)		0.15 (0.04, 0.55)	0.05 (0.01, 0.25)	0.17 (0.07, 0.40)
Serum FGF23		Range, pg/ml		≤21.5		22.5 to 100.9	104.3 to 4844.4
		No. of patients		35		36	35
		No. of MAKE-90		6		18	20
		Model 1		1.00 (Ref)		3.74 (1.18, 11.79)	4.30 (1.34, 13.84)	1.86 (1.17, 2.96)
		Model 2		1.00 (Ref)		5.85 (1.62, 21.18)	4.48 (1.29, 15.53)	1.90 (1.17, 3.10)
FGF23-to-Klotho/Cr ratio		Range, loge x		−2.93 to −0.14		−0.07 to 2.00	2.01 to 6.22
		No. of patients		33		33	33
		No. of MAKE-90		3		13	22
		Model 1		1.00 (Ref)		5.29 (1.29, 21.65)	12.81 (3.03, 54.11)	2.81 (1.58, 5.02)
		Model 2		1.00 (Ref)		6.93 (1.54, 31.10)	11.11 (2.41, 51.29)	2.72 (1.49, 4.96)

Model 1: Adjust for age, sex, Charlson Comorbidity Index

Model 2: Adjusted for age, sex, Charlson Comorbidity Index and non-renal APACHE II score