. Author manuscript; available in PMC: 2020 Apr 8.

Published in final edited form as: J Heart Lung Transplant. 2019 May 7;38(8):845–855. doi: 10.1016/j.healun.2019.05.001

Table 4.

KEGG pathways enriched with ACR

Term	Fold Enrichment	Genes	p Value	FDR
T-cell receptor signaling pathway	21.5	CD247, CD3e, CD8a, CD8b, GRAP2, ITK, LCK, CTLA4, IFNG, PDCD1, ZAP70	2.70E-11	2.90 E-10
Natural killer cell mediated cytotoxicity	17.2	CD247, FASLG, LCK, SH2D1A, GZMB, IFNG, KLRK1, PRF1, ZAP70	2.40E-08	2.60E-07
Primary immunodeficiency	27.9	CD3E, CD8A, CD8B, LCK, ZAP70	2.40E-05	2.60E-04
Cell adhesion molecules	8.7	CD8a, CD8b, TIGIT, CTLA4, PDCD1, VCAM1	4.90E-04	0.0052
Cytokine-cytokine receptor interaction	6.5	CXCL13, CXCR3, CXCR6, FASLG, IFNG, IL2RB	4.90E-04	0.0052
Graft-versus-host disease	24.3	FASLG, GZMB, IFNG, PRF1	5.10E-04	0.0055
Allograft rejection	22.4	FASLG, GZMB, IFNG, PRF1	6.60E-04	0.0070