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. Author manuscript; available in PMC: 2019 Nov 27.
Published in final edited form as: Nat Microbiol. 2019 Sep 2;4(12):2226–2236. doi: 10.1038/s41564-019-0539-x

Figure 4: Female gametes express genes required for genetic recombination and oocyst formation.

Figure 4:

(a-c) Heat maps illustrating expression of genes associated with specific molecular functions that are upregulated in females (by-and-large in vivo and in vitro females concur with some exceptions, n= 4 biological replicates per group). (d) Expression heat maps for all C. parvum AP2 DNA binding proteins. Note pronounced difference identifying four genes upregulated in all females and two only in in vivo females. As we have been unable to sequence males, we cannot formally exclude that some genes that show high female expression may be up regulated in all sexual stages. Expression values are given as row z-score and annotated genes list are available for download as Supplementary files. Genes from the leading edge in Fig. 3b are highlighted in red font.