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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Cancer Immunol Immunother. 2019 Jul 23;68(8):1379–1389. doi: 10.1007/s00262-019-02372-2

Figure 3. ALT-803 enhances NK cell cytotoxicity against SCCHN and ADCC against SCCHN cell lines compared to IL-15 cytokine stimulation.

Figure 3.

Purified human CD56+ NK cells were stimulated overnight in medium alone, ALT-803, or IL-15 (10 ng/ml). The cytolytic activity of NK cells was assessed against A) IgG or B) cetuximab-coated SCCHN cell lines via a standard 4 hour 51Cr release assay. Data represents NK cell cytotoxic activity at the 50:1 effector to target cell ratio. Means ± STD of 3 donors was tested per cell line, *P<0.05 compared to NK+IgG; #P<0.05 compared to IL-15 group.