21st century analytics of continuous vital sign data to prevent diseases in neonates. This illustration depicts a three step-approach combining: a) single or multi-tier analytics of vital signs, b) careful clinical assessment, and c) auxiliary blood and other imaging studies to prevent and decrease morbidity from life-threatening illnesses. HeRo, heart rate characteristics; HRC index, heart rate characteristics index; POPS, pulse oximetry predictive score; BP, blood pressure; CBC, complete blood count; CRP, C-reactive protein; USG, ultrasonography; ABG, arterial blood gas; TCM, transcutaneous carbon dioxide monitoring; NIRS, near infrared spectroscopy; EEG, electroencephalogram; HUS, head ultrasound; NEC, necrotizing enterocolitis; BPD, bronchopulmonary dysplasia; ROP, retinopathy of prematurity; IVH, intraventricular hemorrhage; MCA Doppler, middle cerebral artery Doppler