Table 1.

Summary of compound potencies (μM) with known activity in the CREB pathway identified from screening of the LOPAC library in qHTS

Name	First Run	Second Run	Third Run	Mean ± SD
Forskolin	0.32	0.25	0.25	0.27±0.04
8-(4-Chlorophenylthio)-cAMP	25.12	25.12	15.85	22.03±5.35
8-Bromo-cAMP	25.12	15.85	25.12	22.03±5.35
Papaverine hydrochloride	1.58	0.79	0.79	1.06±0.46
Trequinsin (HL-725)	2.51	1.58	1.26	1.79±0.65
Rolipram	1.26	1.26	2.00	1.50±0.43
Ro 20-1724	5.01	12.59	2.00	6.53±5.46
Etazolate hydrochloride	12.59	15.85	15.85	14.76±1.88
Ibudilast	10.00	12.59	12.59	11.73±1.49
Tracazolate	5.01	5.01	5.01	5.01±0.00
T-1032	12.59	12.59	12.59	12.59±0.00
3-Isobutyl-1-methylxanthine	15.85	15.85	15.85	15.85±0.00
8-Methoxymethyl-3-isobutyl-1-methylxanthine	25.12	15.85	15.85	18.94±5.35
Propentofylline	25.12	25.12	15.85	22.03±5.35
Zardaverine	10.00	15.85	12.59	12.81±2.93