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. Author manuscript; available in PMC: 2020 Mar 31.
Published in final edited form as: Mucosal Immunol. 2019 Oct 9;13(1):64–74. doi: 10.1038/s41385-019-0206-9

Figure 3. Il-22ra2−/− mice have decreased inflammation 5 and 10 days after influenza infection.

Figure 3.

Mice were infected with PR8 (A/PR/8/34, 100 pfu) via oropharyngeal administration. Bronchoalveolar lavage was collected and cells were collected. A) total inflammation from day 5. B) Total inflammation from Day 10 after infection. C) Differential counts from day 5. D) Differential counts from day 10. E) Ratio of M2/M1 macrophages in wildtype vs. il-22ra2−/− mice. F) Cytokine analysis for IL-6, IL-17, Ifnγ and RANTES from lung homogenate. N=8 mice from two independent experiments for A-D. Statistical analysis was performed using one-way ANOVA with Tukey’s post-hoc test or Students T test (E). *p<0.05, **p<0.01 ****p<0.0001