Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A variety of extrinsic factors can damage healthy tissue, resulting in epithelial cell death/apoptosis, local inflammation, and activation of mesenchymal cells (e.g., Fibs). Under physiological conditions, homeostatic repair processes restore healthy tissue. When repair processes fail, Fibs/MFibs become aberrantly and persistently activated, leading to deposition of excess ECM and impaired tissue function.
