Representative axial T2-FLAIR image and maps of macromolecular tissue volume (MTV) reflecting myelin content, axonal volume fraction (AVF), and g-ratio in a patient with RRMS. The top row shows a lesion with an elevated g-ratio (0.95), indicating a greater degree of demyelination relative to axonal loss. The bottom row shows a lesion with concordant axonal and myelin loss, which is reflected by a g-ratio similar to that of NAWM (0.69). For comparison, the conventional T2-FLAIR images do not demonstrate a significant difference in contrast between the two lesions.