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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Cell Mol Life Sci. 2019 Nov 15;77(1):81–91. doi: 10.1007/s00018-019-03367-z

Figure 2: Topoisomerase-2 Cleavage Ligation Equilibrium and Topoisomerase Poisons.

Figure 2:

A. TOP2 Catalytic cycle. TOP2 binding G-segment DNA (Left). TOP2 cleaves DNA generating a double strand break of the G-segment DNA and the reaction intermediate is a TOP2-DPC (right). The presence of TOP2 “poisons” shifts the catalytic cycle equilibrium to favor a trapped DNA complex. B. Examples of the chemical structures of Topoisomerases “poisons” to include: DNA damage substrates, dietary supplements, chemotherapeutics, and environmental toxicants.