. Author manuscript; available in PMC: 2010 Feb 23.

Published in final edited form as: Curr Opin Immunol. 2009 Jun 11;21(3):314–320. doi: 10.1016/j.coi.2009.04.004

Table 2.

Adverse events associated with live smallpox vaccines

Adverse event	Rate of occurrence
Serious and/or life-threatening	(per million vaccinees)
Death	1–2
Postvaccinal Encephalitis	3–9
Progressive Vaccinia	1–7
Eczema Vaccinatum	2–35
Moderate	(per million vaccinees)
Generalized vaccinia	40–200
Myopericarditis	100
Accidental inoculation	100–600
Bacterial Infection	Unknown
Non-infectious rashes	1–5%
Mild (these are far more common, affecting 5–80% of vaccinees)
Itching
Fever
Lymphadenopathy
Headache
Nausea
Pain at vaccination site
Fatigue
Muscle aches
Chills

Adverse reactions noted after smallpox vaccination. Rates of occurrence are based on the data combined from results during the eradication campaign as well as recent civilian and military vaccination campaigns [2,7,8].