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Simulated progression over 36h (a through d) of a representative tumor lesion after exposure to a medium strength ( = 280) of a hypothetical “agent affecting macrophage polarization” (AAMP), simulating an immune therapeutic (as a fraction of the maximum in the vasculature) shifting the M1:M2 ratio to 3.0:1, in conjunction with a bolus injection of MSV-nab-PTX drug-loaded nanoparticles. Colors as in Fig 3. Bar= 200 μm.
