Table 3:
Results of the whole-brain VBM analysis comparing GMV between groups (MetS: n = 104 vs. metabolically healthy control: n = 104
| Metabolic Syndrome VBM Contrast Analysis (n = 208) | ||||||
|---|---|---|---|---|---|---|
| Cluster | Cluster Size (voxels) |
Foci: MNI Coordinates |
Max t-score within cluster |
Cluster Foci: MNI Daemon Label | ||
| x | y | z | ||||
| Brainstem | 13,187 | 2 | −28 | −48 | 4.98 | Pons |
| L. Cerebellum | 28,818 | −24 | −62 | −46 | 5.73 | L. Crus I |
| −44 | −46 | −30 | 3.62 | L. Culmen | ||
| R. Cerebellum | 24,419 | 20 | −66 | −46 | 5.44 | R. Cerebellar Tonsil |
| Orbitofrontal Cortex | 9,175 | 4 | 14 | −24 | 5.66 | R. Rectal Gyrus (BA11) |
| 12 | 62 | −22 | 3.90 | R. Superior Frontal Gyrus (BA10) | ||
| 12 | 44 | −28 | 4.14 | R. Medial Frontal Gyrus (BA11) | ||
| −6 | 14 | −28 | 4.68 | L. Rectal Gyrus | ||
| −12 | 34 | −32 | 3.64 | L. Orbital Gyrus (BA47) | ||
| −2 | 28 | −30 | 4.49 | L. Rectal Gyrus (BA11) | ||
| L. Limbic Lobe | 891 | −16 | −28 | −12 | 3.00 | L. Parahippocampal Gyrus |
| R. Limbic Lobe | 3,071 | 18 | 2 | −18 | 4.25 | Subcallosal Gyrus (BA34) |
| 27 | −2 | −16 | 3.60 | R. Amygdala | ||
| R. Insula | 4,026 | 34 | 0 | −12 | 3.73 | R. Claustrum |
| 42 | −2 | −8 | 3.41 | R. Insula | ||
| L. Caudate | 2,752 | −12 | 16 | 10 | 4.70 | L. Caudate body |
| R. Caudate | 4,054 | 8 | 22 | 8 | 4.59 | R. Caudate Body |
| 6 | 14 | 4 | 4.00 | R. Caudate Body | ||
| Cuneus | 2,787 | −4 | −64 | 8 | 3.51 | L. Cuneus |
| −6 | −84 | 8 | 3.05 | L. Lingual Gyrus | ||
| R. Temporal Lobe | 2,444 | 70 | −24 | 0 | 4.15 | R. Superior Temporal Gyrus (BA22) |
| 68 | −12 | −6 | 3.33 | R. Middle Temporal Gyrus | ||
| Lingual Gyrus | 637 | 8 | −98 | 4 | 3.19 | R. Lingual Gyrus |
L., Left; R., Right; BA, Brodmann Area.
Results are significant at FWE p < 0.05, corrected for multiple comparisons at voxel level.