TABLE 2.

Human uveal melanoma cell lines derived from (a) primary tumors used in mouse xenograft experiments (b) metastases used in mouse xenograft experiments

(a) Cell line (mutations)	Source	Original publication (Laboratory of origin)	Inoculation method	Metastasis	References
Mel92.1 (GNAQQ209L; EIF1AXG6D)	Primary tumor	De Waard-Siebinga et al. (1995) (Martine Jager)	Subcutaneous	Not reported	Faiao-Flores et al. (2019); Forsberg et al. (2019); Kines et al. (2018); Chen et al. (2017, 2014); Ambrosini, Sawle, Musi, and Schwartz (2015); Ambrosini, Musi, Ho, Stanchina, and Schwartz, (2013); Musi, Ambrosini, Stanchina, and Schwartz, (2014); Surriga et al. (2013); Ho et al. (2012); Samadi et al. (2012); Landreville et al. (2012)
			Suprachoroidal	Liver	Dong et al. (2019)
				Not reported	Yu et al. (2014)
			Ant. chamber	Liver	Ma and Niederkorn (1998), Ma, Luyten, Luider, Jager, and Niederkorn (1996)
			Tail vein	Liver and lungs	Matatall et al. (2013)
			Intrasplenic	Liver	Barisione et al. (2015); Gangemi et al. (2014, 2012)
Mel202 (GNAQQ209L; SF3B1R625G)	Primary tumor	Ksander, Rubsamen, Olsen, Cousins, and Streilein (1991) (J. Wayne Streilein)	Subcutaneous	Not reported	Forsberg et al. (2019)
			Ant. chamber	Liver	Ma and Niederkorn (1998), Ma, Luyten, Luider, Jager, and Niederkorn (1996)
			Intravitreal	Not reported	Yoo et al. (2016)
			Tail vein	Liver	Niederkorn, Mellon, Pidherney, Mayhew, and Anand (1993)
Mel270 (GNAQQ209P)	Primary tumor	Verbik, Murray, Tran, and Ksander (1997) (Bruce Ksander)	Suprachoroidal	Not reported	Yu et al. (2014)
			Subcutaneous	Liver and lungs	Tafreshi et al. (2019)
				Lot reported	Voropaev et al. (2019); Annala et al. (2019); Kaochar et al. (2018)
			Intrasplenic	Liver	Barisione et al. (2015); Gangemi et al. (2014, 2012)
MP41 (GNA11Q209L)	PDX from a primary tumor	Amirouchene-Angelozzi et al. (2014) (Sergio Roman-Roman)	Tail vein	Liver	Faiao-Flores et al. (2019)
T105 and T142 (GNA11Q209L)	Primary tumors	Mouriaux et al. (2016) (Sylvain Guérin)	Subcutaneous	Not reported	Mouriaux et al. (2016)
UMT2 (GNA11Q209L)	Primary tumors	Suesskind et al. (2013) (Sigrid Henke-Fahle)	Suprachoroidal	None	Süsskind, Hurst, Rohrbach, and Schnichels (2017)
(b) Cell line	Source	Original publication (Laboratory of origin)	Inoculation site	Metastasis	References
OMM1 (GNA11Q209L)	Subcutis metastasis	Luyten et al. (1996) (Theo Luider)	Subcutaneous	Not reported	Zhou, Jin, Jin, Liu, and Pan (2017); Wang, Liu, Jin, Jiang, and Pan (2017); Sutmuller et al. (2000)
			Ant. chamber	Liver	Repp, Mayhew, Howard, Alizadeh, and Niederkorn (2001)
			Tail vein	Liver	Ma and Niederkorn (1995)
OMM1.3a = OMM2.3 (GNAQQ209P)	Liver metastasis	Verbik et al. (1997) (Bruce Ksander)	Subcutaneous	Not reported	Ambrosini et al. (2019); Jin et al. (2018); Vaqué et al. (2013)
			Suprachoroidal	Liver	Liang et al. (2012); Zhu et al. (2010)
			Retro-orbital	Liver and lungs	Surriga et al. (2013)
			Intrasplenic	Liver	Jin et al. (2018)
TJU-UM001 (GNAQQ209P)	Liver metastasis	Yoshida et al. (2014) (Takami Sato)	Intrahepatic	Peritoneum, lymph nodes	Kageyama et al. (2017); Ozaki et al. (2016); Cheng et al. (2015)
			Intrasplenic	Liver	Piquet et al. (2019); Ozaki et al. (2016)
TJU-UM004 (GNAQQ209P)	Orbital metastasis	Cheng et al. (2015) (Takami Sato)	Intrahepatic	None	Kageyama et al. (2017)

Abbreviation: Ant. chamber: anterior chamber.

^aThe Mel270 cell line was derived from this patient’s primary tumor. The OMM2.5 cell line (also called OMM1.5) is derived from another liver metastasis in the same patient.