. Author manuscript; available in PMC: 2020 May 26.

Published in final edited form as: JCO Precis Oncol. 2019 Aug 14;3:10.1200/po.19.00029. doi: 10.1200/PO.19.00029

TABLE 3.

Kaplan-Meier Estimates of Overall Survival Associated With Adjuvant Chemotherapy in Patients With Grade 3 Invasive Breast Cancer, Stratified by pN Status and RS

RS^*	Total (No.)	Had Chemotherapy (%)	5-Year Overall Survival Rate, % (95% CI)		P
RS^*	Total (No.)	Had Chemotherapy (%)	No Chemotherapy	Chemotherapy	P
pN0
Low	3,591	9.1	96.3 (95.0 to 97.2)	98.8 (94.9 to 99.7)	.07
Intermediate	5,304	54.9	93.0 (90.8 to 94.7)	95.5 (94.0 to 96.6)	.002
High	4,332	89.4	79.6 (72.4 to 85.1)	91.8 (90.2 to 93.1)	< .001
No RS	7,586	52.2	83.3 (81.3 to 85.0)	93.6 (92.4 to 94.7)	< .001
pN1
Low	821	25.9	92.0 (86.9 to 95.2)	93.0 (80.7 to 97.6)	.27
Intermediate	1,188	64.4	85.7 (77.5 to 91.1)	93.2 (88.4 to 96.1)	.02
High	726	88.3	66.9 (48.6 to 79.9)	92.4 (88.1 to 95.2)	< .001
No RS	6,880	82.8	70.6 (66.5 to 74.3)	90.7 (89.5 to 91.8)	< .001

NOTE. Boldface indicates significance at P < 05.

Abbreviation: RS, recurrence score.

In 2.4% of patients (n = 331) with pN0 and 3.7% (n = 105) with pN1 grade 3 tumors who underwent RS testing, the RS score was not available.