FIGURE 1.
Microgliosis occurs in the MBH throughout PDAC cachexia. (a) Representative confocal microscopy images of Iba-1 immunoreactivity within the MBH, hippocampus, and cortex from either a sham, 7 dpi, or 10 dpi mouse brain. Scale bar = 100 µm. Top left inset = arcuate nucleus microglia within left box. Top right inset = median eminence microglia within right box. Inset scale bars = 10 µm. B-E) Analysis of microglia number (left) or percent area Iba-1+ (right) in the arcuate nucleus, median eminence, hippocampus, or cortex. n.s. = not significant, ***p < .001, **p < .01, *p < .05 compared to sham in one-way ANOVA analysis