FIGURE 7.

PLX5622 administration minimally effects liver inflammation during PDAC. (a) Quantification of different immune cell populations in the liver from sham animals and PDAC-bearing animals. 10D = 10 days post inoculation. (b) qRT-PCR of select inflammatory transcripts in the livers of PDAC-bearing animals at 7 or 10 days post inoculation. For each transcript, values are normalized to that from 7 dpi. AIN tumor-bearing group. ***p < .001, **p < .001 *p < .05 comparing AIN group to PLX56222 group in Bonferroni post hoc analysis in one-way ANOVA. For all experiments, n = 3–4/group