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EAA uptake inhibition enhances stimulation of CREB-dependent gene transcription by cAMP. The EAA uptake inhibitor, TBOA (10 μM), did not, by itself, stimulate 4xCRE transcription, but potentiated the response induced by forskolin (1 μM) or 8-Br-cAMP (1 mM). ***, significantly different from forskolin, 8-Br-cAMP or TBOA alone (p<.01).
