Fig. 1. Flowchart of analyses and datasets used.
Six independent cohorts were assessed. These included the discovery sample, three replication cohorts, and two post-mortem brain cohorts. AUD= alcohol use disorder, FDR= false discovery rate, GS= Generation Scotland: Scottish Family Health Study, GTP= Grady Trauma Project, WCGNA= weighted genome co-regulation network analysis, BOLD= blood oxygen level-dependent, fMRI= functional magnetic resonance imaging, MRI= magnetic resonance imaging, GAS5= growth arrest specific 5, FKBP5= FK506-binding protein 5.