Table 1:

Association of DNA methylation with AUD status across multiple cohorts

		Discovery Cohort (N=539)			Replication Cohort (N=86)			Generation Scotland (N=4301)			Grady Trauma Project (N=391)
Probe ID	Gene	b	SE	Adj P	b	SE	Adj P	b	SE	Adj P	b	SE	Adj P
Negative Associations
cg06644515	GAS5a; SNORD47	−0.015	0.003	0.00054	−0.044	0.0071	0.0028	−0.017	0.0017	3.0×10–24	−0.022	0.0064	0.00071
cg15130459	SNORD72;RPL37	−0.016	0.0044	0.04	−0.044	0.0089	0.033	−0.0062	0.0023	0.0079	−0.025	0.0085	0.0044
cg20813374	FKBP5	−0.02	0.0036	0.00014	−0.045	0.0091	0.03	−0.0032	0.002	0.12	−0.014	0.0054	0.011
cg01940273		−0.056	0.006	0.006	−0.078	0.013	0.0028	−0.011	0.0026	0	−0.023	0.009	0.012
cg14316231	MYST3	−0.012	0.003	0.028	−0.04	0.0083	0.038	−0.0046	0.002	0.023	−0.014	0.0058	0.018
cg21566642		−0.072	0.0078	0.008	−0.11	0.017	0.0025	0.0032	0.0025	0.2	−0.028	0.012	0.023
cg16290996	GAS5b; SNORD78	−0.014	0.0031	0.0039	−0.043	0.0076	0.0089	−0.014	0.0025	0	−0.018	0.0078	0.025
cg18917643		−0.027	0.0036	0.004	−0.057	0.01	0.0098	−0.015	0.0023	0	−0.013	0.0061	0.034
cg00505318	UBA3	−0.012	0.0022	0.00037	−0.026	0.0053	0.03	−0.0054	0.0018	0.0024	−0.018	0.0088	0.037
cg10558233		−0.026	0.0053	9.00E-04	−0.066	0.013	0.031	−0.0083	0.0032	0.0095	−0.022	0.01	0.039
cg27537125		−0.013	0.0019	0.002	−0.024	0.0045	0.012	NA	NA	NA	−0.009	0.0043	0.039
cg15705813		−0.021	0.0029	0.003	−0.038	0.0063	0.0039	−0.013	0.0018	0	−0.014	0.007	0.046
cg25537245	LINC01126	−0.0061	0.0014	0.01	−0.016	0.0035	0.049	−0.0072	0.0021	0.00046	−0.0052	0.003	0.085
cg18159646	SNORD22;SNHG1	−0.0082	0.0022	0.034	−0.029	0.0052	0.0099	−0.011	0.0015	3.0×10–12	−0.0094	0.0062	0.13
cg02583484	HNRNPA1	−0.03	0.0033	0.003	−0.048	0.0085	0.0093	−0.013	0.0019	0	−0.0089	0.0068	0.19
cg03603381	RASGRP1	−0.015	0.003	0.00052	−0.038	0.0079	0.038	−0.0056	0.0015	0.00011	−0.0072	0.0056	0.2
cg25615944	RPL37	−0.011	0.0028	0.003	−0.035	0.0065	0.012	−0.02	0.0029	0	−0.0084	0.0084	0.32
cg15408734		−0.0075	0.0015	0.00065	−0.02	0.0038	0.014	−0.0064	0.0023	0.0062	−0.003	0.003	0.33
cg18696027	B2M	−0.0087	0.0021	0.011	−0.027	0.0047	0.0089	−0.0067	0.0024	0.005	0.0016	0.0061	0.79
cg20625334	STAM2	−0.026	0.004	0.004	−0.061	0.012	0.023	−0.012	0.0023	0	−0.002	0.0078	0.8
cg22158648		−0.012	0.0028	0.0091	−0.035	0.007	0.03	−0.0062	0.0018	0.00048	0.001	0.007	0.88
cg13683827	FAM113B	−0.01	0.0023	0.0054	−0.032	0.0059	0.012	−0.0069	0.0016	0	−4.00E-04	0.005	0.94
cg05575921	AHRR	−0.1	0.011	1.50E-13	−0.14	0.024	0.0037	−0.016	0.0048	0.00059	NA	NA	NA
Positive Associations
cg08109625	PRKCZ	0.011	0.003	0.044	0.036	0.007	0.023	0.0017	0.0017	0.3	0.015	0.0068	0.027
cg20005742		0.02	0.0049	0.014	0.064	0.013	0.038	0.0099	0.0026	1.00E-04	0.016	0.0079	0.049
cg14334350	NOTCH1	0.017	0.0034	0.00072	0.044	0.0078	0.0089	0.0098	0.0019	0	0.011	0.0064	0.077
cg04406114	POU2F2	0.0097	0.0021	0.0034	0.024	0.0048	0.034	0.0052	0.0015	0.00053	0.0087	0.0062	0.16
cg11095027	TOLLIP	0.024	0.0032	6.58E-09	0.033	0.0067	0.033	0.0081	0.0015	3×10–8	0.0053	0.0069	0.45
cg09975715	MYH10	0.019	0.0033	3.75E-05	0.042	0.0084	0.028	0.0045	0.0018	0.013	0.0022	0.0047	0.64
cg15554126	PEX14	0.011	0.0029	0.041	0.036	0.0063	0.0089	0.0073	0.0017	0	−0.002	0.0043	0.65
cg11589723	GLTSCR1	0.011	0.0023	0.00065	0.031	0.0065	0.045	0.013	0.0028	0	−0.00075	0.0023	0.75