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. Author manuscript; available in PMC: 2011 Feb 5.
Published in final edited form as: Virology. 2009 Nov 24;397(1):187. doi: 10.1016/j.virol.2009.11.001

Figure 3. Neutralizing antibody titer in RVF VLP-vaccinated mice determined by plaque reduction neutralization tests.

Figure 3

Mouse sera were collected after three immunizations with RVF chimVLPs, RVF VLPs with or without RVFV N, Ebolavirus GP-pseudotyped MoMLV (Control 1) and from unimmunized mice (Control 2). The neutralizing antibody titer was determined as the reciprocal of the dilution of five two-fold serial dilutions of sera, respectively. Neutralizing antibody titer is considered positive at the lowest initial serum dilution that results in >80% (PRNT80) reduction of the number of plaques as compared to the virus control.