Figure 2. Mouse models for aortic valve malformations:

Illustrations represent a tricuspid aortic valve (A) and a bicuspid aortic valve, BAV (B). Right (R), left (L) and noncoronary (NC) leaflets are labelled. BAV were demonstrated in endothelial specific deletion of Notch1 (Nfatc1^enCre; Notch1^fl/fl) (D) and in Gata5^−/− (F) mice compared to normal three leaflet structure found in wildtype mice (C, E). (C, D) and (E, F) have been adapted from Wang et al. 2017 and Laforest et al. 2011 with permission.