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. Author manuscript; available in PMC: 2020 Aug 28.
Published in final edited form as: Cell Rep Med. 2020 May 19;1(2):100013. doi: 10.1016/j.xcrm.2020.100013

Table 3.

Univariate Predictors and Reversals Selected in Discovery and Confirmed in Blinded Verification

Univariate/Bivariate Numerator Denominator GABD Window Discovery Mean AUC—Full DiscoveryMean AUC—Early Discovery Mean AUC—Middle Discovery Mean AUC—Late VerificationMean AUC—Full Verification Mean AUC—Early
B hsa-miR-127–3p hsa-miR-485–5p F 0.66a 0.57 0.61a 0.70a 0.67b 0.70b
B hsa-miR-4732–3p hsa-miR-941 E 0.55 0.81a 0.57 0.58 0.53 0.80a
B hsa-miR-1273h-3p hsa-miR-3173–5p E 0.57 0.83a 0.57 0.53 0.62a 0.82a
B hsa-miR-155–5p hsa-miR-3173–5p E 0.56 0.76a 0.55 0.50 0.58 0.76a
B hsa-miR-150–3p hsa-miR-193b-5p M 0.63a 0.76a 0.73a 0.58 0.70a 0.58
B hsa-miR-1285–3p hsa-mir-378c M 0.56 0.61a 0.70a 0.54 0.65b 0.63b
B hsa-miR-4732–3p hsa-miR-381–3p E 0.53 0.82a 0.63a 0.57 0.50 0.80a
B hsa-miR-320b hsa-miR-155–5p L 0.58 0.62a 0.60a 0.70a 0.54 0.70a
B hsa-miR-181a-5p hsa-miR-155–5p L 0.59 0.58 0.59 0.70a 0.52 0.70a
B hsa-miR-26b-5p hsa-miR-155–5p L 0.59 0.53 0.61a 0.69a 0.55 0.65a
B hsa-let-7g-5p hsa-miR-155–5p L 0.59 0.58 0.60 0.70a 0.53 0.69a
B hsa-miR-4443 hsa-miR-155–5p L 0.57 0.64a 0.56 0.72a 0.53 0.73a
B hsa-miR-425–5p hsa-miR-155–5p L 0.58 0.60 0.58 0.70a 0.54 0.69a
B hsa-miR-146a-5p hsa-miR-155–5p L 0.57 0.63a 0.54 0.70a 0.57 0.61a
B hsa-miR-25–3p hsa-miR-155–5p L 0.59 0.57 0.57 0.71a 0.52 0.75a
B hsa-miR-151a-3p hsa-miR-155–5p L 0.58 0.63a 0.57 0.71a 0.54 0.70a
B hsa-miR-320a hsa-miR-155–5p L 0.58 0.62a 0.61a 0.71a 0.54 0.69a
B hsa-miR-30d-5p hsa-miR-155–5p L 0.58 0.64a 0.56 0.71a 0.54 0.71a
B hsa-miR-126–3p hsa-miR-155–5p L 0.58 0.62a 0.57 0.70a 0.55 0.67a
B hsa-miR-146b-5p hsa-miR-155–5p L 0.57 0.64a 0.55 0.70a 0.56 0.63a
B hsa-let-7i-5p hsa-miR-155–5p L 0.60a 0.60a 0.61a 0.74a 0.55 0.69a
B hsa-miR-26a-5p hsa-miR-155–5p L 0.56 0.65a 0.56 0.70a 0.54 0.69a
B hsa-miR-625–3p hsa-miR-155–5p L 0.58 0.64a 0.59 0.73a 0.54 0.67a
B hsa-miR-423–5p hsa-miR-155–5p L 0.59 0.60 0.59 0.70a 0.55 0.73a
B hsa-miR-451a hsa-miR-155–5p L 0.61a 0.57 0.60a 0.72a 0.54 0.69a
B hsa-miR-125a-5p hsa-miR-155–5p L 0.58 0.63a 0.61a 0.71a 0.51 0.75a
B hsa-miR-99a-5p hsa-miR-155–5p L 0.58 0.60a 0.56 0.70a 0.56 0.68a
B hsa-let-7b-5p hsa-miR-155–5p L 0.60 0.60 0.61a 0.71a 0.54 0.75a
B hsa-miR-516b-5p hsa-miR-155–5p L 0.55 0.72a 0.47 0.70a 0.54 0.72a
B hsa-miR-363–3p hsa-miR-155–5p L 0.59 0.58 0.61a 0.70a 0.53 0.73a
U hsa-miR-516b-5p E 0.49 0.81a 0.64a 0.59 0.54 0.75a
U hsa-miR-941 M 0.65 0.69a 0.70a 0.64a 0.56 0.49

Information pertaining to the GABD window, performance (area under the curve [AUC]) in the discovery and verification cohorts, tissue sources (calculated), and associated carrier subclasses (calculated) is listed. Mean AUCs for discovery and verification sets for each GABD window. Chromosome: chromosome on which each miRNA is encoded. miRNA Cluster: if a given miRNA is located in a miRNA cluster, a “Y” is entered. Tissue Atlas: for each miRNA. The cell or tissue type with the highest percentage, and with percentages within 10 percentage points of the highest percentages, are listed in decreasing abundance in the “max/(max – 10%)” columns. Associated Carrier Subclasses: for miRNAs that show differential enrichment in one or more carrier subclasses by immunoprecipitation, the enriched subclass(es) are listed. See also Tables S3 and S4 and Figure S2. E, early; F, full; L, late; M, middle.

a

Mean AUC values between 0.6 and 0.8.

b

miRNAs for which the verification mean AUCs for each GABD window and averaged across all GABD windows columns are >0.6.