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. Author manuscript; available in PMC: 2020 Jun 30.
Published in final edited form as: Glia. 2020 Feb 8;68(7):1445–1465. doi: 10.1002/glia.23792

Figure 3: Following a photolytic lesion, Müller glia and Müller glia-derived progenitors express mmp-9.

Figure 3:

These experiments were performed using the transgenic line Tg[gfap:EGFP]mi2002, in which eGFP is expressed in Müller glia. (A) Triple labeling using in situ hybridization for mmp-9 (red) and immunostaining for BrdU for dividing cells (white), combined with GFP immunostaining (green). (B) Number of BrdU+ cells that express mmp-9 in unlesioned animals and lesioned animals at 24, 48, and 72 hpl. (C) Number of GFP+ Müller glia that also express mmp-9 expression at 24, 48, and 72 hpl. ONL- outer nuclear layer; INL- inner nuclear layer; GCL- ganglion cell layer. Scale bar equals 25μm.