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. Author manuscript; available in PMC: 2021 Mar 13.
Published in final edited form as: Mucosal Immunol. 2020 Jul 16;14(2):491–499. doi: 10.1038/s41385-020-0322-6

Figure 5. CD153+ polyfunctional Mtb300-specific CD4 cells are phenotypically less activated and differentiated than CD153- polyfunctional cells.

Figure 5.

a Representative flow cytometry overlay plots of CD27, HLA-DR, KLRG1 and Eomes expression in CD153+IL2+IFNγ+TNFα+ (pink) and CD153-IL2+IFNγ+TNFα+ (black) Mtb300-specific CD4 T cells in one LTBI and one aTB participant. b Summary graph of the expression of CD27, HLA-DR, KLRG1 and Eomes in CD153+IL2+IFNγ+TNFα+ [CD153+] and CD153-IL2+IFNγ+TNFα+ [CD153-] Mtb300-specific CD4 T cells in LTBI (left) and aTB (right) participants. Only CD153+IL2+IFNγ+TNFα+ and CD153-IL2+IFNγ+TNFα+ sub-populations with more than 30 events were considered for phenotyping. Statistical comparisons were performed using a paired non-parametric Wilcoxon test. (****P < 0.0001, ***P < 0.001, **P < 0.01, *P <0.05).