Table 2.

Histone deacetylase (HDAC) phosphorylation in physiological processes and disease

Protein	Process/ Disease	References
HDAC1	Osteoblast differentiation, Diet-induced obesity, Hepatosteatosis	[103,120]
HDAC2	Cardiac hypertrophy, Diet-induced obesity, Hepatosteatosis, Neurodegenerative diseases, Alzheimer’s disease, COPD-related inflammation	[28,29,68,110,120,130]
HDAC3	HER2-positive breast cancer, Parkinson’s disease, Glycolysis	[33,34,112]
HDAC4	Glioblastoma, Skeletal myogenesis, Muscle cell differentiation, Cardiac hypertrophy, Gluconeogenesis, Myelin sheath development	[61,85,86,97,104,105,113]
HDAC5	Glioblastoma, Immune signaling, Skeletal myogenesis, Muscle cell differentiation, Angiogenesis, Cardiac hypertrophy, Gluconeogenesis, Insulin resistance (Type II diabetes, obesity), Neuronal differentiation, Synaptic plasticity, Depression, Cocaine-reward behavior	[57,60,85,86,98,99,104,107,108,113,114,127,128,158]
HDAC6	Neurodegenerative diseases, Mitochondrial transport	[41,129]
HDAC7	Glioblastoma, Immune signaling, Muscle cell differentiation, Angiogenesis, Gluconeogenesis	[85,86,101,102,113]
HDAC9/ MITR	Glioblastoma, Muscle cell differentiation	[85,86,99]
SIRT1	Liver cancer, Osteosarcoma, Diet-induced obesity, NAFLD, Lipid homeostasis, Hepatosteatosis, Atherosclerosis, DNA damage response	[44,48,69,84,89,118,121,122,126]
SIRT2	Microglial inflammation, Listeria monocytogenes infection	[95,96]
SIRT3	Colon carcinoma, Triple-negative breast cancer, Glioblastoma	[87]
SIRT6	HER2-positive breast cancer	[73]
SIRT7	Cardiac fibrosis	[111]