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. Author manuscript; available in PMC: 2020 Aug 11.
Published in final edited form as: J Vitreoretin Dis. 2020 Jul 1;4(4):269–279. doi: 10.1177/2474126420930863

Figure 3.

Figure 3.

A 78-year-old man with intraocular inflammation progressing to symptomatic occlusive retinal vasculitis in the left eye 34 days after his first (and only) brolucizumab injection. (A) Early-phase fluorescein angiography revealed diffuse retinal arterial and venous filling defects with extensive ischemia and choroidal hypoperfusion in several small multifocal areas. (B) Late-phase fluorescein angiography images demonstrated persistent arterial and venous filling defects, focal leakage around arterioles and venules, slowly resolving choroidal hypoperfusion, and mild optic nerve hyperfluorescence. (C) Optical coherence tomography showed hyperreflective thickening of the inner retinal layers in the nasal macula, consistent with acute retinal ischemia.