Table 1.
Experiments on the database.
| Study No. | Animals | Experiment name | Tissue | Lighting | Sampling times | Notes | Reps | Refs |
|---|---|---|---|---|---|---|---|---|
| 101 | Chicken, White Leghorn | Pineal gland and retina; time series; constant darkness | PG, R | D:D | CT 0, 4, 8, 12, 16, 20 | N/A | 3 | N/A |
| 102 | Human | Pineal gland; day and night | PG | L:D 12:12 | ZT 6, 18 | N/A | 2, 4 | N/A |
| 103 | Mouse, 129sv | Pineal gland, retina and mixed tissue; day and night; Eya2 KO | PG, R, MT | L:D 12:12 | ZT 6, 18 | Eya2 KO | 1 | N/A |
| 104 | Rat, Sprague Dawley | Pineal gland; day and night; and mixed tissue, day; polyA | PG, MT | L:D 14:10 | ZT 7, 19 | N/A | 1 | 23 |
| 105 | Rat, Sprague Dawley | Pineal gland development; day and night | PG | L:D 14:10 | ZT 7, 19 | Ages: E21, P5, P20, P40 | 1 | 23, 24 |
| 106 | Rat, Sprague Dawley | Pineal gland (RP), retina (RR) and mixed tissue (RX); 24-hr time series | PG, R, MT | L:D 14:10 | ZT 1, 7, 13, 15, 19, 23 | N/A | 1 | 23 |
| 107 | Rat, Sprague Dawley | Pineal gland; day and night; and mixed tissue, day; Ribominus | PG, MT | L:D 14:10 | ZT 7, 19 | N/A | 1 | 23 |
| 108 | Rat, Sprague Dawley | Pineal gland; superior cervical decentralization (DCN) or ganglionectomy (SCGX); day and night | PG | L:D 14:10 | ZT 7, 19 | DCN, SCGX, Sham, Control | 3 | 8 |
| 109 | Rat, Sprague Dawley | Pineal gland in vitro; norepinephrine (NE) or dibutyryl cyclic AMP (DBcAMP) | PG | N/A | N/A | Cultured glands; NE, DBcAMP, Control | 3 | 8 |
| 110 | Rat, Sprague Dawley | Pineal gland marker genes; day and night | PG | L:D 14:10 | ZT 7, 19 | N/A | 1 | 23 |
| 111 | Rhesus macaque | Pineal gland, retina and mixed tissue; time series | PG, R, MT | L:D 12:12 | ZT 6, 12, 18, 24 | Dawn, Day, Dusk, Night | 3 | 12 |
| 112 | Zebrafish | Pineal gland; time series; constant darkness | PG | D:D | CT 2, 6, 10, 14, 18, 22 | N/A | 2 | 7 |
| 113 | Zebrafish | Eye, pineal gland and mixed tissue; day and night | Eye, PG, MT | L:D 12:12 | ZT 6, 18 | clocka KO | 1 | N/A |
Thirteen experiments encompassing six species are on the website; additional experiments are to be added as data become available. Experimental details are available on the website (https://snengs.nichd.nih.gov/experiments) and the listed references. Abbreviations: CT, circadian time; DD, constant darkness; L:D, light:dark; MT, mixed tissue; N/A, not available; PG, pineal gland; R, retina; Reps, number of replicates; Refs, references; RP, rat pineal gland; RR, rat retina; RX rat mixed tissue; ZT, Zeitgeber time.