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. Author manuscript; available in PMC: 2021 Jan 27.
Published in final edited form as: Pain. 2021 Feb 1;162(2):446–458. doi: 10.1097/j.pain.0000000000002033

Figure 5. Minocycline treatment induces upregulation of antiinflammatory and antinociceptive factors in the spinal dorsal horns of disulfide HMGB1-subjected male but not female mice.

Figure 5.

Bar graphs depict the effect size in protein expression of (A) A1AT5, (B) A1AT4, (C) A1AT2, (D) SAP3K, (E) SAP3N, (F) HPT, (G) VTDB and (H) HEMO between i) male vs. female injected with disulfide HMGB1, ii) males injected with disulfide HMGB1-minocycline compared to disulfide HMGB1-vehicle and iii) females injected with disulfide HMGB1-minocyline compared to disulfide HMGB1-vehicle. Data are presented as relative levels in log2 scale, n=6 mice/group.