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. Author manuscript; available in PMC: 2020 Sep 24.
Published in final edited form as: Circ Res. 2020 Jul 30;127(8):997–1022. doi: 10.1161/CIRCRESAHA.120.317295

Figure 6. Depletion of basement-membrane proteins in ruptured human carotid plaques and in aortas of SR-uPA+/0 mice.

Figure 6.

(A) Data from 2 sets of human carotid plaques. Shotgun proteomics was performed on stable (open bars) and ruptured (shaded bars) segments of two independent sets of plaques (1 and 2). Analyses were performed independently, 1 year apart. Proteins were selected for this analysis based on their significantly decreased abundance in the first set of human plaques and—for basement-membrane proteins—congruently decreased abundance in SR-uPA+/0 mouse aortas. (B) Data from aortas of 20-week-old SR-uPA+/0 and SR-uPA0/0 mice. (A and B) Individual data points (n=6 per group) indicate individual plaque segments (A) or aortas (B); group medians and interquartile ranges are shown. PSM= peptide-spectrum match. P values: #<0.1, *<0.05, **<0.01 ***<0.005.