Table 1.
Cytoskeletal, Cell Adhesion, and Extracellular Matrix Proteins with Significantly Different Abundance in Aortas of SR-uPA+/0 Mice
| Cytoskeletal Proteins* Increased in SR-uPA+/0 aortas |
Cell Adhesion Proteins† Increased in SR-uPA+/0 aortas |
Extracellular Matrix Proteins‡ Decreased in SR-uPA+/0 aortas |
||||||
|---|---|---|---|---|---|---|---|---|
| Protein | SR-uPA+/0 | SR-uPA0/0 | Protein | SR-uPA+/0 | SRuPA0/0 | Protein | SR-uPA+/0 | SR-uPA0/0 |
| ARPC1B | 7.4 ± 2.5 | 1.6 ± 0.6 | HDLBP | 9 ± 3.3 | 1.9 ± 1.4 | EMILIN1 | 3.2 ± 1.7 | 11.5 ± 2.9 |
| CAPZB | 11 ± 2.5 | 5.8 ± 1.7 | ACTB | 57.1 ± 6.8 | 42.9 ± 8 | LTBP4 | 17.9 ± 5 | 40.4 ± 4.3 |
| CFL1 | 15.8 ± 2.7 | 9.9 ± 1.2 | ARPC1B | 7.4 ± 2.5 | 1.6 ± 0.6 | AGRN | 9.3 ± 2.7 | 21.3 ± 2.4 |
| MYH9 | 42.6 ± 10.1 | 22.7 ± 5.6 | CAPZB | 11 ± 2.5 | 5.8 ± 1.7 | ATP5B | 70.4 ± 8.1 | 95.9 ± 13 |
| LCP1 | 10.3 ± 1.1 | 6.2 ± 2.2 | CFL1 | 15.8 ± 2.7 | 9.9 ± 1.2 | COL15A1 | 18.3 ± 5.1 | 29.8 ± 5.8 |
| SPTBN1 | 14.4 ± 4.5 | 4.1 ± 1.6 | EEF2 | 18 ± 2.2 | 10.7 ± 3.7 | COL1A2 | 12.2 ± 3.5 | 18.2 ± 2.9 |
| CORO1C | 3.9 ± 1.1 | 1.5 ± 1.3 | GNB2 | 9.5 ± 1.8 | 4.3 ± 0.3 | ELN | 8.7 ± 2.9 | 15 ± 2.5 |
| FLNB | 9.3 ± 1.1 | 2.1 ± 1.4 | PDIA3 | 46.5 ± 4.5 | 36.6 ± 4.7 | FN1 | 309.3 ± 35.9 | 399.7 ± 40.9 |
| SEPT9 | 3 ± 0.9 | 0.5 ± 0.8 | RPS2 | 10.3 ± 1.6 | 6.2 ± 1.2 | HSPG2 | 207.4 ± 16.3 | 272.8 ± 17.5 |
| ACTN4 | 28.7 ± 2.3 | 14.5 ± 2.4 | ANXA1 | 28.9 ± 3.4 | 22.2 ± 3.1 | LAMA5 | 16.4 ± 2.2 | 35.8 ± 7.8 |
| AHNAK | 54.2 ± 9.7 | 36.2 ± 6.7 | LRP1 | 16.2 ± 3.4 | 7.8 ± 0.4 | LAMB2 | 53.2 ± 5.3 | 70.7 ± 5 |
| ACTB | 57.1 ± 6.8 | 42.9 ± 8 | MYH9 | 42.6 ± 10.1 | 22.7 ± 5.6 | LOXL1 | 38.9 ± 3.2 | 58.9 ± 8.4 |
| MAP4 | 4.7 ± 3 | 0.4 ± 0.6 | PLAU | 17.4 ± 6.5 | 0 ± 0 | NID1 | 39.6 ± 5.3 | 64.3 ± 7.7 |
| PLEC | 25.8 ± 2.3 | 7.8 ± 2.2 | PLEC | 25.8 ± 2.3 | 7.8 ± 2.2 | NID2 | 21.9 ± 3.3 | 31.5 ± 1.3 |
| TCP1 | 15.1 ± 1.9 | 8.2 ± 2.7 | LCP1 | 10.3 ± 1.1 | 6.2 ± 2.2 | EFEMP1 | 2.5 ± 1.2 | 11.8 ± 4.1 |
| MVP | 21.5 ± 3.4 | 12.2 ± 3.2 | RPS5 | 4.3 ± 1.3 | 1.9 ± 0.7 | SERPINE2 | 8.9 ± 3 | 16.9 ± 2.2 |
| RCC1 | 4.1 ± 1 | 1.8 ± 1.4 | SPTBN1 | 14.4 ± 4.5 | 4.1 ± 1.6 | VTN | 17.9 ± 4.2 | 25.3 ± 3.9 |
| ANXA1 | 28.9 ± 3.4 | 22.2 ± 3.1 | THY1 | 2.8 ± 0.6 | 0.7 ± 0.9 | WISP2 | 6.4 ± 2.3 | 10.8 ± 2 |
| THY1 | 2.8 ± 0.6 | 0.7 ± 0.9 | HSP90B1 | 41.6 ± 2.6 | 24.7 ± 5.3 | FBLN5 | 46.5 ± 5.6 | 80.1 ± 10.5 |
| HSP90B1 | 41.6 ± 2.6 | 24.7 ± 5.3 | CORO1C | 3.9 ± 1.1 | 1.5 ± 1.3 | POSTN | 51.4 ± 5.3 | 63.2 ± 3.7 |
| ANXA8 | 8.5 ± 2.3 | 3.7 ± 1.2 | FLNB | 9.3 ± 1.1 | 2.1 ± 1.4 | HTRA1 | 13.5 ± 6.7 | 29.8 ± 2.5 |
| EEF2 | 18 ± 2.2 | 10.7 ± 3.7 | SEPT9 | 3 ± 0.9 | 0.5 ± 0.8 | MFAP4 | 36 ± 5.9 | 47.4 ± 6 |
| GNB1 | 13.4 ± 2.2 | 3.9 ± 1.1 | SND1 | 10.1 ± 5.4 | 2.8 ± 1.2 | PLG | 10.3 ± 6.6 | 22.2 ± 5.6 |
| VCP | 31.3 ± 5.8 | 19 ± 4 | ACTN4 | 28.7 ± 2.3 | 14.5 ± 2.4 | BCAM | 5.5 ± 3.5 | 12 ± 3.1 |
| AHNAK | 54.2 ± 9.7 | 36.2 ± 6.7 | LAMC1 | 50.5 ± 5.9 | 64.2 ± 6.4 | |||
| RPL4 | 16.7 ± 2.1 | 11.5 ± 2.5 | ||||||
| PUF60 | 5.8 ± 1.2 | 3 ± 1.2 | ||||||
| DDOST | 10.9 ± 3 | 5.5 ± 2 | ||||||
Data are mean ± SD. All differences were significant (FDR< 0.05; Online Data Set II)
Includes all proteins in GO categories: 0015629 (actin cytoskeleton), 0030863 (cortical cytoskeleton), 0005856 (cytoskeleton), 0007010 (cytoskeleton organization), or 0008092 (cytoskeletal protein binding).
Includes all proteins in GO categories: 005912 (adherens junction), 005925 (focal adhesion), or 0007155 (cell adhesion).
Includes all proteins in GO categories: 0031012 (extracellular matrix), 00030198 (extracellular matrix organization), 0050840 (extracellular matrix binding), 0005201 (extracellular matrix structural constituent, or 0005604 (basement membrane; these are in bold type).