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. Author manuscript; available in PMC: 2021 Aug 27.
Published in final edited form as: Vaccine. 2020 Jul 30;38(38):6007–6018. doi: 10.1016/j.vaccine.2020.07.018

Figure 4.

Figure 4.

Evaluation of antibody responses after short-term vaccination of groups of mice with B5V formulations and pathogenesis after VACV challenge. A to C. Sera samples were obtained 3 weeks after one boost vaccination and antibody responses were measured by ELISA. (A) total IgG; (B) isotype IgG1; (C) isotype IgG2a. Mice (10 mice/group) were then challenged intranasally with VACV 3.7×105 pfu per mouse and followed for (D) weight loss and (E) survival rate. Solid symbols represent vaccines formulated in Alhydrogel (AH). Open symbols represent vaccines formulated in phosphate treated Alhydrogel (PTAH). Solid lines represent vaccines formulated with CpG. Dashed lines represent vaccines formulated without CpG.