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. Author manuscript; available in PMC: 2020 Sep 8.
Published in final edited form as: Cell Mol Life Sci. 2015 Dec 26;73(9):1927–1937. doi: 10.1007/s00018-015-2118-5

Fig. 7.

Fig. 7

Mutation-induced alterations of ABCG2 interaction with different types of inhibitors. The efflux of mitoxantrone by HEK293 cells expressing either wild-type ABCG2 (circles) or the S353A mutant (triangles) was measured by flow cytometry as in Fig. 4. Its inhibition by increasing concentrations of Ko143 (a), chromone 1 (b) or nilotinib (c) was plotted as indicated