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. Author manuscript; available in PMC: 2020 Oct 19.
Published in final edited form as: Brain Behav Immun Health. 2020 Apr 29;5:100077. doi: 10.1016/j.bbih.2020.100077

Fig. 2.

Fig. 2.

HIV-1 Tat does not affect compulsive-like or social behaviors in novel environments. After 8 weeks of DOX administration, Tat exposure did not affect orbitofrontal cortex-mediated compulsive measures of marbles buried (A) or percentage of nestlet shredded (C). Tat exposure for up to 8 weeks also did not change mobility in the marble-burying test, but in both Tat(−) and Tat(+) mice mobility did decrease over time (B). Tat(+) and Tat(−) mice did not differ in time spent interacting in reciprocal (novel mouse free; 2–6 weeks) and non-reciprocal (novel mouse was restrained under a pencil cup; 8 weeks) social interaction assays (D). Data are presented as mean ± SEM, n = 12 mice per group. Main effect of exposure time, #p < 0.05 vs 2 weeks of DOX.