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The relationship between changes in ketamine and peripheral inflammation (measured by C-reactive protein (CRP) one day post-infusion) with changes in functional connectivity (measured two days post-infusion) between the ventral rostral putamen (VRP) and right orbitofrontal cortex (OFC). Data are plotted separately for healthy volunteers (HVs; p=0.007) and individuals with treatment-resistant depression (TRD; p=0.77). Δ: ketamine minus placebo
