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. Author manuscript; available in PMC: 2020 Dec 11.
Published in final edited form as: J Thromb Haemost. 2020 Aug 28;18(11):2899–2909. doi: 10.1111/jth.15037

Figure 1: Effect of FXII and FXI deficiency on venous thrombus formation in the mouse IVC stasis and IVC stenosis models.

Figure 1:

FXII and FXI deficient mice were subject to the IVC stasis model or IVC stenosis models of venous thrombosis and compared to wildtype littermate controls. (A) Thrombus weight at 48 hours post-induction did not differ significantly between F12−/− mice and F12+/+ controls in the IVC stasis model (n=7 per group). (B) In the IVC stasis model a small non-significant decrease in thrombus weight was observed in F11−/− mice compared to F11+/+ controls (n=8 per group). ns P>0.05 Student’s t-test. Thrombus weight data is represented as individual values with a line for the mean. (C) In the IVC stenosis model F12−/− mice demonstrated a significant reduction in median thrombus weight at 48 hours post-induction compared to F12+/+ controls (n=11–12 per group). (D) A significant reduction in the incidence of venous thrombus formation in F12−/− mice was observed compared to F12+/+ controls. (E) F11−/− mice subject to the IVC stenosis model demonstrated a significant reduction in median thrombus weight at 48 hours post-induction compared to F11+/+ controls (n=13–14 per group). (F) A significant reduction in the incidence of venous thrombus formation in F11−/− mice was observed compared to F11+/+ controls. * P<0.05, Mann-Whitney U test, **P<0.05 Fischer’s exact test. Thrombus weight data is represented as individual values with a line for the median.