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. Author manuscript; available in PMC: 2020 Dec 11.
Published in final edited form as: J Thromb Haemost. 2020 Aug 28;18(11):2899–2909. doi: 10.1111/jth.15037

Figure 4: Effect of FXII or FXI deficiency on venous thrombus formation in the mouse femoral vein electrolytic model of thrombosis.

Figure 4:

Thrombus formation in F12−/− and F12+/+ controls was assessed using the femoral vein electrolytic injury model (n=4 per group). (A) A marked reduction in temporal accumulation of fibrin was observed. (B) Area under the curve measurements demonstrated a significant decrease in total fibrin accumulation at the site of injury in F12−/− mice compared to F12+/+ controls. (C) Similarly, a marked reduction in temporal platelet accumulation was observed in F12−/− compared to F12+/+ controls. (D) Area under the curve measurements demonstrated a significant decrease in total platelet accumulation at the site of injury in F12−/− mice compared to F12+/+ controls. Thrombus formation in F11−/− and F11+/+ controls was assessed using the femoral vein electrolytic injury model (n=4–5 per group). (E) A marked reduction in temporal fibrin accumulation was evident in F11−/− mice compared to F11+/+ controls. (F) Area under the curve measurement demonstrated a significant reduction in total fibrin accumulation. (G) A marked reduction in platelet accumulation was also observed in F11−/− mice compared to F11+/+ controls. (H) Area under the curve measurements revealed a significant reduction in total platelet accumulation in F11−/− mice compared to F11+/+ controls. * P<0.001, **P<0.0001, ***P<0.01 Student’s t-test. Data represented at mean ± SEM.