Table 1:

Comparative effects of FXII and FXI deficiency in mouse venous thrombosis models

Approach	Model	Phenotype	Ref
ASO	St Thomas’	Targeting FXII and FXI with high level knockdown equally protective	18
KO	IVC stenosis	FXII deficiency, but not FXI deficiency, protective	19
siRNA	FVEI	Targeting FXII more protective than FXI for intermediate level knockdown	61
KO	IVC stenosis	FXII and FXI deficiency equally protective	Current Study
KO	IVC stasis	FXII and FXI deficiency not protective	Current Study
KO	FVEI	FXII and FXI deficiency equally protective	Current Study

antisense oligonucleotide, ASO; inferior vena cava, IVC; short interfering RNA, siRNA, femoral vein electrolytic injury, FVEI; knockout, KO